Projects Sponsored by the CLL Foundation

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          RESEARCH STUDIES:

• Examining the Impact of Certain Genetic Variances on the Heritability of Chronic Lymphocytic Leukemia. Principal Investigator: Jennifer Brown, M.D., Ph.D., of the Dana-Farber Cancer Institute.
• Profiling the Proteomics of CLL and Related Cancers. Lead Investigator: Steven Kornblau, M.D., of the University of Texas MD Anderson Cancer Center.
• Investigating the impact of the SF3B1 gene mutation on the interaction between an isoform of the PP2A gene and the BCL2 gene and the relation between the mutation and resistance to the drug ABT 199 Lead investigators: Drs. Peter Ruvolo and Steven Kornblau of the University of Texas MD Anderson Cancer Center.
• Examining a Novel Combinational Approach in Testing Mutant p53-dependent CLL. Lead Investigator: Sean M. Post, Ph.D., University of Texas MD Anderson Cancer Center.
• Screening for Inhibitors of Bcl-2-IP3R Interaction. A Final Report. Lead Investigator:Clark W. Distelhorst, M.D., Case Western Reserve School of Medicine
• Screening for Inhibitors of Bcl-2-IP3R Interaction. Lead Investigator:Clark W. Distelhorst, M.D., Case Western Reserve School of Medicine
• A Genetic Approach to the Adoptive T Cell Therapy for CLL-Progress Report.  Lead investigator:  Renier J. Brentjens
• A Genetic Approach to the Adoptive T Cell Therapy for CLL.  Lead investigator:  Renier J. Brentjens, M.D., Memorial Sloan-Kettering Cancer Center.  Dr. Brentjen's study was funded as a memorial to the late William D. Hoops, founder and first president of the Chronic Lymphocytic Leukemia Foundation.
• Differential Gene Expression in CLL Cells. Lead investigator:  Shantaram S. Joshi, Ph.D., University of Nebraska Medical Center. 
• Global Methylation Profile of CLL Patients and its Implication in Therapy. Progress Report.  Lead Investigator:  Wei-Gang Tong
• Global Methylation Profile of CLL Patients and its Implication in Therapy.  Lead Investigator:  Wei-Gang Tong, M.D., Ph.D., University of Texas M.D. Anderson Cancer Center.  The grant to Dr. Tong was made possible by the bequest of Dwight R. Hubert. 
• Development of a Pharmacological Activator of STAT 1 for the Targeted Therapy of Chronic Lymphocytic Leukemia.  Lead investigator:  David A. Frank, M.D. Ph.D.,Dana Farber Cancer Institute.  The grant to Dr. Frank was made possible by the bequest of Dwight R. Hubert. 
• Analysis of Data from Phase II Study of Genesense (BCL-2 antisense) in Patients with Advanced Chronic Lympocytic Leukemia."  Investigators:  Drs. Susan O'Brien, Michael Keating, Michael Andreeff, and other physicians from the University of Texas M.D. Anderson Cancer Center. 
• Progress Report on The Use of the BH3 Inhibitor, PI3K, To Overcome Stroma-Mediated Resistance.
  Lead investigator: Matthew S. Davids, M.D., Dana-Farber Cancer Institute
• The Use of the BH3 Inhibitor, PI3K, To Overcome Stroma-Mediated Resistance.
  Lead investigator: Matthew S. Davids, M.D., Dana-Farber Cancer Institute

       PATIENT EDUCATION:

• Sponsored and participated in the making of the HealthTalk video:
  Participating in a Clinical Trial:  A Patient's Story.
  The story of Andrew Shorr's treatment in the Rituxan, Fludarabine and Cytoxan trial at MD Anderson Cancer Center.
• Sponsored the HealthTalk recording of the:
  CLL Patient Conference at Johns Hopkins Oncology Center on March 24, 2001
  Discussion on new therapies and developments for CLL,  an overview of the drug approval process and new developments at the FDA,  effective communication with your doctor from the physician's perspective and also recent immunologic approaches to CLL